Blar i forfatter "Greiner-Tollersrud, Linn"
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Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN
Robertsen, Børre; Greiner-Tollersrud, Linn; Jørgensen, Lars Gaute (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-06)Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection. Analysis of the Atlantic salmon genome revealed the presence of 9 Mx genes localized to three chromosomes. A cluster of three Mx genes (SsaMx1 – SsaMx3), which includes previously cloned Mx genes, is present on chromosome (Chr) 12. A cluster of five Mx genes (SsaMx4-SsaMx8) is present on Chr25 while one Mx gene ... -
Atlantic salmon possesses two clusters of type I interferon receptor genes on different chromosomes, which allows for a larger repertoire of interferon receptors than in zebrafish and mammals
Sun, Baojian; Greiner-Tollersrud, Linn; Koop, Ben F; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
CRISPR-Cas– induced IRF3 and MAVS knockouts in a salmonid cell line disrupt PRR signaling and affect viral replication
van der Wal, Yorick Andreas; Nordli, Henriette R.; Akandwanaho, Allan; Greiner-Tollersrud, Linn; Kool, Jaap; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)Background: Interferon (IFN) responses are critical in the resolution of viral infections and are actively targeted by many viruses. They also play a role in inducing protective responses after vaccination and have been successfully tested as vaccine adjuvants. IFN responses are well conserved and function very similar in teleosts and mammals. Like in mammals, IFN responses in piscine cells are ... -
The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection
van der Wal, Yorick Andreas; Jenberie, Shiferaw; Nordli, Henriette; Greiner-Tollersrud, Linn; Kool, Jaap; Jensen, Ingvill; Jørgensen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-01)The intraperitoneal route is favored for administration of inactivated and attenuated vaccines in Atlantic salmon. Nevertheless, the immune responses in the teleost peritoneal cavity (PerC) are still incompletely defined. In this study, we investigated the B cell responses after intraperitoneal Piscirickettsia salmonis (P. salmonis) challenge of Atlantic salmon, focusing on the local PerC response ... -
Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish
Bela-Ong, Dennis; Greiner-Tollersrud, Linn; van der Wal, Yorick Andreas; Jensen, Ingvill; Seternes, Ole Morten; Jørgensen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in antiviral defense. Members of this protein family contain distinctive multiple structural motifs comprising tetratricopeptides that are tandemly arrayed or dispersed along the polypeptide. IFIT-encoding genes are upregulated by type I interferons (IFNs) and other stimuli. IFIT proteins inhibit virus replication by ... -
Infectious pancreatic necrosis virus proteins VP2, VP3, VP4 and VP5 antagonize IFNa1 promoter activation while VP1 induces IFNa1
Lauksund, Reidunn Silje; Greiner-Tollersrud, Linn; Chang, Chia Jung; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)Infectious pancreatic necrosis virus (IPNV) is one of the major viral pathogens causing disease in farmed Atlantic salmon worldwide. In the present work we show that several of the IPN proteins have powerful antagonistic properties against type I IFN induction in Atlantic salmon. Each of the five IPNV genes cloned into an expression vector were tested for the ability to influence activation of the ...